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Larotrectinib is a first-in-class potent and highly selective inhibitor of TRK kinases.

In this first-in-human, phase I dose-escalation study, we showed that larotrectinib was well tolerated and provided consistent and durable antitumour activity in adults with TRK fusion cancer.

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Though less common, alterations in BRAF/HER2 and MAP2K1 (MEK) are additional biomarkers of primary resistance to anti-EGFR [5–7].

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